Shiv Pillai

Lymphocyte Development: Cell Selection Events and Signals During Immune Ontogeny Shiv Pillai

Description for Sales People: "Lymphocyte Development" presents an extremely up-to-date account of molecular processes involved in the development of lymphocytes. Topics include the selection processes involved in B and T lymphocyte maturation, immune receptor gene rearrangement, signaling pathways involved in cell cycle progression and apoptosis, and the transcriptional regulation of lymphoid ontogeny. It will interest researchers in immunology and it will be useful as a supplementary text for a graduate level immunology course. Table of Contents: 1 Overview of Cell Fate Decisions During Lymphoid Ontogeny.- 2 Commitment to a Lymphoid Fate.- 3 V(D) J Recombination and the Generation of Diversity.- 4 Pathways Mediating Signal Transduction and Cell Cycle Progression in Lymphocytes.- 5 Molecular Mechanisms of Lymphocyte Apoptosis.- 6 Lymphocyte Homing and the Generation of Secondary Lymphoid Organs.- 7 The Generation of Naive B Lymphocytes.- 8 Antigen-Induced B-Lymphocyte Differentiation.- 9 T Lymphocyte Development.- 10 The Activation and Differentiation of Mature T Lymphocytes.- 11 The Development of Natural Killer Cells.- 12 Naturally Occurring Disorders of Lymphocyte Development.

Contributor Bio:  Pillai, Shiv Pillai, MGH Cancer Center, Harvard Medical School, Boston, MA.