Pritesh Ranjan Dash

Phytochemical Screening and Pharmacological Investigations on Hedychium coronarium Pritesh Ranjan Dash

The present study was carried out for phytochemical screening and pharmacological investigations on methanolic extract of rhizomes of Hedychium coronarium (Local name: Dolan Champa, Family: Zingiberaceae). In this study, the possible analgesic and CNS (Central Nervous System) depressant activities of the methanolic rhizome extract of Hedychium coronarium were investigated at the doses of 100 mg/Kg, 200 mg/kg and 400 mg/Kg body weight on mice by oral administration. The analgesic activities were investigated for their central and peripheral pharmacological actions using tail immersion testing and acetic acid-induced writhing testing respectively. Its CNS depressant activity was evaluated by using hole cross and open field tests and the cytotoxic activity was observed using brine shrimp lethality bioassay.