Aditya Nath Pandey

Design & Evalution of Valsartan and Hydrochlorothiazide Coated Tablets Aditya Nath Pandey

Tablets are solid unit dosage form of medicaments with or without suitable diluents and prepared either by molding or compression. They are solid, flat or biconvex disc in shape. They vary greatly in shape, size and weight which depend upon amount of medicament used and mode of administration. They also vary in hardness, thickness, disintegration and dissolution characteristics and in other aspects depending upon their intended use and method of manufacture. Tablets are the most widely used solid dosage form of medicament. Because of their advantages their popularity is continuously increasing day by day. Hypertension is a very common disorder, particularly past middle age. It is not a disease in itself, but it is an important risk factor for cardiovascular mortality and morbidity. The WHO-ISH guidelines defined it to 140 mm Hg systolic and 90 mm Hg diastolic, through risk appears to increase even above 120/90 mm Hg.