Vincent J Merluzzi

The Search for Anti-inflammatory Drugs Vincent J Merluzzi Softcover Reprint of the Original 1st Ed. 1995 edition

Jacket Description/Back: This book will be a valuable asset for a medical or university library, as well as for researchers and clinicians. It will make an enticing reading for non-specialists interested in the history behind modern pharmacology, and can be used as a textbook in graduate courses. Table of Contents: 1 The Discovery of Drugs to Treat Arthritis: A Historical View.- 2 The History of the Discovery and Development of Cyclosporine (Sandimmune(r)).- 3 Discovery and Development of FK506 (Tacrolimus), A Potent Immunosuppressant of Microbial Origin.- 4 Discovery of Sulindac, a Reversible Prodrug, as a Second-Generation Indomethacin.- 5 The Discovery of Zileuton (Leutrol(r)).- 6 Discovery of Accolate (ICI 204,219), a Peptide Leukotriene Antagonist for Asthma.- 7 Discovery of ZD2138, a Potent, Selective, Well-Tolerated, Nonredox Inhibitor of the Enzyme 5-Lipoxygenase.- 8 Development of MK 0591: An Orally Active Leukotriene Biosynthesis Inhibitor with a Novel Mechanism of Action.- 9 Discovery of BIRM 270: A New Class of Leukotriene Biosynthesis Inhibitors.- 10 Discovery and Development of the Immunomodulatory Azaspiranes.- Keyword Index."