Richard Baker

Prion Diseases - Methods in Molecular Medicine Richard Baker 1996 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: The Paradox of Prion Disease. Human Spongiform Encephalopathy: Clinical Presentation and Diagnostic Tests. Neuropathological Diagnosis of Human Prion Disease: Morphological Studies. Neuropathological Diagnosis of Human Prion Disease: PrP Immunocytochemical Techniques. The Diagnosis of Bovine Spongiform Encephalopathy (BSE) and Scrapie by Detection of BSE Fibrils or Scrapie-Associated Fibrils (SAF) by Transmission Electron Microscopy and of the Abnormal Protein Isoform (PrPSc) by Immunoblotting. Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies. Surveillance of Prion Diseases in Humans. Environmental Causes of Human Spongiform Encephalopathy. Bovine Spongiform Encephalopathy: Methods of Analyzing the Epidemic in the United Kingdom. Handling the BSE Epidemic in Great Britain. Special Problems of Genetic Counseling in Adult Onset Diseases: Huntington's Disease as a Model. Genotyping and Susceptibility of Sheep to Scrapie. Strain Typing Studies of Scrapie and BSE. PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies. Transgenic Approaches to Prion 'Species-Barrier' Effects. Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems. Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy. Index. Review Quotes: Prion Diseases is a timely publication... Scientists already established in the subject as well as those embarking on such research for the first time will find the book useful. I also recommend it as a well structured text..-British Medical JournalPublisher Marketing: This volume discusses such areas as the surveillance of prion diseases, methods of preventing infection by prion diseases, neuropathological diagnosis of prion diseases, utilization of immunotechniques for the diagnosis of prion diseases, and the pathogenesis of prion disease.